| Rank | Player | Matches | Wins | Losses | PCT | 6-0 | 0-6 |
| 1 | Andy Murray GBR | 87 | 78 | 9 | 0.897 | 8 | 0 |
| 2 | Dominic Thiem AUT | 80 | 56 | 24 | 0.700 | 5 | 1 |
| 3 | Kei Nishikori JPN | 78 | 57 | 21 | 0.731 | 3 | 0 |
| 4 | Novak Djokovic SRB | 74 | 65 | 9 | 0.878 | 3 | 1 |
| 5 | David Goffin BEL | 74 | 49 | 25 | 0.662 | 5 | 2 |
| 6 | Marin Cilic CRO | 71 | 48 | 23 | 0.676 | 2 | 0 |
| 7 | Milos Raonic CAN | 69 | 52 | 17 | 0.754 | 2 | 2 |
| 8 | Roberto Bautista Agut ESP | 69 | 46 | 23 | 0.667 | 1 | 2 |
| 9 | Alexander Zverev GER | 68 | 44 | 24 | 0.647 | 1 | 3 |
| 10 | Pablo Carreno Busta ESP | 66 | 40 | 26 | 0.606 | 3 | 4 |
| 11 | Grigor Dimitrov BUL | 65 | 39 | 26 | 0.600 | 0 | 1 |
| 12 | Albert Ramos-Vinolas ESP | 65 | 34 | 31 | 0.523 | 6 | 0 |
| 13 | Stan Wawrinka SUI | 64 | 46 | 18 | 0.719 | 0 | 0 |
| 14 | Viktor Troicki SRB | 63 | 34 | 29 | 0.540 | 2 | 0 |
| 15 | Gael Monfils FRA | 61 | 44 | 17 | 0.721 | 4 | 2 |
| 16 | Tomas Berdych CZE | 59 | 39 | 20 | 0.661 | 2 | 2 |
| 17 | Gilles Muller LUX | 59 | 35 | 24 | 0.593 | 0 | 1 |
| 18 | Gilles Simon FRA | 59 | 33 | 26 | 0.559 | 5 | 1 |
| 19 | Jack Sock USA | 58 | 37 | 21 | 0.638 | 1 | 2 |
| 20 | David Ferrer ESP | 58 | 36 | 22 | 0.621 | 2 | 0 |
| 21 | Steve Johnson USA | 58 | 30 | 28 | 0.517 | 0 | 1 |
| 22 | Joao Sousa POR | 58 | 25 | 33 | 0.431 | 1 | 2 |
| 23 | Pablo Cuevas URU | 57 | 34 | 23 | 0.596 | 1 | 1 |
| 24 | Lucas Pouille FRA | 56 | 34 | 22 | 0.607 | 1 | 2 |
| 25 | Ivo Karlovic CRO | 56 | 32 | 24 | 0.571 | 0 | 0 |
| 26 | Feliciano Lopez ESP | 55 | 31 | 24 | 0.564 | 1 | 1 |
| 27 | Fernando Verdasco ESP | 55 | 29 | 26 | 0.527 | 1 | 1 |
| 28 | Benoit Paire FRA | 55 | 23 | 32 | 0.418 | 1 | 5 |
| 29 | Nick Kyrgios AUS | 54 | 39 | 15 | 0.722 | 1 | 0 |
| 30 | Jo-Wilfried Tsonga FRA | 54 | 37 | 17 | 0.685 | 0 | 1 |
| 31 | John Isner USA | 54 | 33 | 21 | 0.611 | 1 | 0 |
| 32 | Bernard Tomic AUS | 54 | 30 | 24 | 0.556 | 0 | 0 |
| 33 | Adrian Mannarino FRA | 54 | 26 | 28 | 0.481 | 1 | 2 |
| 34 | Richard Gasquet FRA | 53 | 35 | 18 | 0.660 | 4 | 2 |
| 35 | Philipp Kohlschreiber GER | 53 | 32 | 21 | 0.604 | 1 | 2 |
| 36 | Guillermo Garcia-Lopez ESP | 53 | 22 | 31 | 0.415 | 1 | 1 |
| 37 | Rafael Nadal ESP | 52 | 39 | 13 | 0.750 | 6 | 0 |
| 38 | Sam Querrey USA | 51 | 28 | 23 | 0.549 | 2 | 0 |
| 39 | Federico Delbonis ARG | 51 | 27 | 24 | 0.529 | 2 | 1 |
| 40 | Paolo Lorenzi ITA | 51 | 26 | 25 | 0.510 | 4 | 3 |