| Rank | Player | Matches | Wins | Losses | PCT | 6-0 | 0-6 |
| 1 | Rafael Nadal ESP | 41 | 34 | 7 | 0.829 | 4 | 1 |
| 2 | Nikolay Davydenko RUS | 35 | 26 | 9 | 0.743 | 3 | 0 |
| 3 | Nicolas Almagro ESP | 34 | 25 | 9 | 0.735 | 0 | 0 |
| 4 | Novak Djokovic SRB | 32 | 28 | 4 | 0.875 | 6 | 0 |
| 5 | David Ferrer ESP | 32 | 22 | 10 | 0.688 | 2 | 2 |
| 6 | James Blake USA | 32 | 22 | 10 | 0.688 | 1 | 0 |
| 7 | Roger Federer SUI | 31 | 25 | 6 | 0.806 | 3 | 0 |
| 8 | Stanislas Wawrinka SUI | 31 | 20 | 11 | 0.645 | 2 | 0 |
| 9 | Igor Andreev RUS | 29 | 15 | 14 | 0.517 | 0 | 3 |
| 10 | Andy Murray GBR | 28 | 19 | 9 | 0.679 | 4 | 1 |
| 11 | Jose Acasuso ARG | 28 | 15 | 13 | 0.536 | 1 | 0 |
| 12 | Juan Monaco ARG | 27 | 17 | 10 | 0.630 | 2 | 1 |
| 13 | Sam Querrey USA | 27 | 17 | 10 | 0.630 | 0 | 1 |
| 14 | Andy Roddick USA | 26 | 21 | 5 | 0.808 | 0 | 0 |
| 15 | Radek Stepanek CZE | 26 | 17 | 9 | 0.654 | 1 | 1 |
| 16 | Mardy Fish USA | 26 | 16 | 10 | 0.615 | 0 | 0 |
| 17 | Paul-Henri Mathieu FRA | 26 | 15 | 11 | 0.577 | 1 | 0 |
| 18 | Carlos Moya ESP | 26 | 14 | 12 | 0.538 | 1 | 0 |
| 19 | Simone Bolelli ITA | 26 | 14 | 12 | 0.538 | 1 | 0 |
| 20 | Juan Carlos Ferrero ESP | 25 | 15 | 10 | 0.600 | 0 | 0 |
| 21 | Fernando Verdasco ESP | 25 | 13 | 12 | 0.520 | 2 | 0 |
| 22 | Gilles Simon FRA | 25 | 13 | 12 | 0.520 | 0 | 0 |
| 23 | David Nalbandian ARG | 24 | 17 | 7 | 0.708 | 1 | 1 |
| 24 | Robin Soderling SWE | 24 | 16 | 8 | 0.667 | 1 | 0 |
| 25 | Janko Tipsarevic SRB | 24 | 14 | 10 | 0.583 | 2 | 2 |
| 26 | Andreas Seppi ITA | 24 | 13 | 11 | 0.542 | 2 | 0 |
| 27 | Tommy Robredo ESP | 24 | 13 | 11 | 0.542 | 0 | 1 |
| 28 | Marin Cilic CRO | 24 | 12 | 12 | 0.500 | 0 | 0 |
| 29 | Ivo Karlovic CRO | 24 | 12 | 12 | 0.500 | 0 | 0 |
| 30 | Mario Ancic CRO | 23 | 16 | 7 | 0.696 | 1 | 1 |
| 31 | Michael Llodra FRA | 23 | 14 | 9 | 0.609 | 0 | 1 |
| 32 | Dmitry Tursunov RUS | 23 | 13 | 10 | 0.565 | 0 | 1 |
| 33 | Agustin Calleri ARG | 23 | 12 | 11 | 0.522 | 0 | 1 |
| 34 | Jarkko Nieminen FIN | 23 | 10 | 13 | 0.435 | 1 | 0 |
| 35 | Mikhail Youzhny RUS | 22 | 14 | 8 | 0.636 | 2 | 2 |
| 36 | Jo-Wilfried Tsonga FRA | 21 | 13 | 8 | 0.619 | 1 | 2 |
| 37 | Philipp Kohlschreiber GER | 21 | 13 | 8 | 0.619 | 0 | 0 |
| 38 | Potito Starace ITA | 21 | 10 | 11 | 0.476 | 1 | 0 |
| 39 | Juan Ignacio Chela ARG | 21 | 10 | 11 | 0.476 | 0 | 0 |
| 40 | Albert Montanes ESP | 21 | 10 | 11 | 0.476 | 0 | 0 |