| Rank | Player | Matches | Wins | Losses | PCT | 6-0 | 0-6 |
| 1 | Novak Djokovic SRB | 59 | 47 | 12 | 0.797 | 3 | 0 |
| 2 | Andy Murray GBR | 51 | 45 | 6 | 0.882 | 3 | 1 |
| 3 | Rafael Nadal ESP | 47 | 42 | 5 | 0.894 | 6 | 1 |
| 4 | Roger Federer SUI | 44 | 38 | 6 | 0.864 | 3 | 0 |
| 5 | Andy Roddick USA | 44 | 36 | 8 | 0.818 | 2 | 0 |
| 6 | Tommy Robredo ESP | 47 | 34 | 13 | 0.723 | 3 | 1 |
| 7 | Juan Martin Del Potro ARG | 40 | 30 | 10 | 0.750 | 1 | 2 |
| 8 | Fernando Verdasco ESP | 42 | 30 | 12 | 0.714 | 4 | 0 |
| 9 | Jo-Wilfried Tsonga FRA | 39 | 29 | 10 | 0.744 | 1 | 1 |
| 10 | David Ferrer ESP | 44 | 29 | 15 | 0.659 | 2 | 0 |
| 11 | Marin Cilic CRO | 39 | 28 | 11 | 0.718 | 5 | 2 |
| 12 | Radek Stepanek CZE | 39 | 28 | 11 | 0.718 | 3 | 2 |
| 13 | Fernando Gonzalez CHI | 31 | 24 | 7 | 0.774 | 2 | 0 |
| 14 | Gilles Simon FRA | 38 | 24 | 14 | 0.632 | 2 | 0 |
| 15 | Tommy Haas GER | 31 | 22 | 9 | 0.710 | 0 | 1 |
| 16 | Philipp Kohlschreiber GER | 34 | 22 | 12 | 0.647 | 1 | 1 |
| 17 | Lleyton Hewitt AUS | 34 | 22 | 12 | 0.647 | 2 | 0 |
| 18 | Juan Carlos Ferrero ESP | 32 | 21 | 11 | 0.656 | 1 | 0 |
| 19 | Jeremy Chardy FRA | 38 | 21 | 17 | 0.553 | 2 | 1 |
| 20 | Gael Monfils FRA | 29 | 20 | 9 | 0.690 | 0 | 0 |
| 21 | Stanislas Wawrinka SUI | 30 | 20 | 10 | 0.667 | 1 | 0 |
| 22 | Mardy Fish USA | 34 | 20 | 14 | 0.588 | 1 | 0 |
| 23 | Juan Monaco ARG | 33 | 19 | 14 | 0.576 | 3 | 2 |
| 24 | Mikhail Youzhny RUS | 35 | 19 | 16 | 0.543 | 0 | 0 |
| 25 | Nikolay Davydenko RUS | 26 | 18 | 8 | 0.692 | 1 | 0 |
| 26 | James Blake USA | 30 | 18 | 12 | 0.600 | 0 | 1 |
| 27 | Robin Soderling SWE | 30 | 18 | 12 | 0.600 | 1 | 1 |
| 28 | Tomas Berdych CZE | 32 | 18 | 14 | 0.563 | 2 | 0 |
| 29 | Guillermo Garcia-Lopez ESP | 33 | 18 | 15 | 0.545 | 3 | 1 |
| 30 | Igor Andreev RUS | 35 | 18 | 17 | 0.514 | 1 | 0 |
| 31 | Nicolas Almagro ESP | 29 | 17 | 12 | 0.586 | 1 | 0 |
| 32 | Ivan Ljubicic CRO | 31 | 17 | 14 | 0.548 | 0 | 0 |
| 33 | Ivo Karlovic CRO | 31 | 17 | 14 | 0.548 | 0 | 0 |
| 34 | Viktor Troicki SRB | 32 | 17 | 15 | 0.531 | 1 | 3 |
| 35 | Sam Querrey USA | 33 | 17 | 16 | 0.515 | 0 | 0 |
| 36 | Paul-Henri Mathieu FRA | 34 | 17 | 17 | 0.500 | 0 | 1 |
| 37 | Jurgen Melzer AUT | 32 | 16 | 16 | 0.500 | 2 | 4 |
| 38 | Albert Montanes ESP | 32 | 16 | 16 | 0.500 | 2 | 2 |
| 39 | Janko Tipsarevic SRB | 30 | 15 | 15 | 0.500 | 2 | 3 |
| 40 | Andreas Seppi ITA | 33 | 15 | 18 | 0.455 | 1 | 0 |