| Rank | Player | Matches | Wins | Losses | PCT | 6-0 | 0-6 |
| 1 | Rafael Nadal ESP | 71 | 63 | 8 | 0.887 | 8 | 1 |
| 2 | Novak Djokovic SRB | 54 | 44 | 10 | 0.815 | 8 | 0 |
| 3 | Roger Federer SUI | 55 | 44 | 11 | 0.800 | 5 | 1 |
| 4 | Nikolay Davydenko RUS | 52 | 39 | 13 | 0.750 | 3 | 0 |
| 5 | David Ferrer ESP | 51 | 36 | 15 | 0.706 | 4 | 2 |
| 6 | Andy Murray GBR | 47 | 35 | 12 | 0.745 | 6 | 2 |
| 7 | James Blake USA | 49 | 33 | 16 | 0.673 | 2 | 0 |
| 8 | Fernando Verdasco ESP | 52 | 33 | 19 | 0.635 | 5 | 1 |
| 9 | Gilles Simon FRA | 49 | 31 | 18 | 0.633 | 1 | 0 |
| 10 | Nicolas Almagro ESP | 42 | 30 | 12 | 0.714 | 0 | 0 |
| 11 | Stanislas Wawrinka SUI | 44 | 29 | 15 | 0.659 | 3 | 0 |
| 12 | Igor Andreev RUS | 50 | 29 | 21 | 0.580 | 0 | 3 |
| 13 | Robin Soderling SWE | 41 | 27 | 14 | 0.659 | 2 | 2 |
| 14 | Mario Ancic CRO | 39 | 26 | 13 | 0.667 | 2 | 1 |
| 15 | Tommy Robredo ESP | 42 | 26 | 16 | 0.619 | 0 | 1 |
| 16 | Andy Roddick USA | 33 | 25 | 8 | 0.758 | 0 | 0 |
| 17 | Dmitry Tursunov RUS | 41 | 25 | 16 | 0.610 | 3 | 1 |
| 18 | Marin Cilic CRO | 44 | 25 | 19 | 0.568 | 0 | 0 |
| 19 | Juan Monaco ARG | 37 | 24 | 13 | 0.649 | 2 | 1 |
| 20 | Fernando Gonzalez CHI | 32 | 23 | 9 | 0.719 | 2 | 0 |
| 21 | Radek Stepanek CZE | 37 | 23 | 14 | 0.622 | 3 | 1 |
| 22 | Ivo Karlovic CRO | 41 | 23 | 18 | 0.561 | 0 | 0 |
| 23 | Sam Querrey USA | 41 | 23 | 18 | 0.561 | 0 | 1 |
| 24 | Mikhail Youzhny RUS | 36 | 22 | 14 | 0.611 | 3 | 2 |
| 25 | Richard Gasquet FRA | 37 | 22 | 15 | 0.595 | 1 | 1 |
| 26 | Andreas Seppi ITA | 42 | 22 | 20 | 0.524 | 2 | 0 |
| 27 | David Nalbandian ARG | 31 | 21 | 10 | 0.677 | 1 | 2 |
| 28 | Philipp Kohlschreiber GER | 35 | 21 | 14 | 0.600 | 0 | 0 |
| 29 | Paul-Henri Mathieu FRA | 39 | 21 | 18 | 0.538 | 2 | 0 |
| 30 | Simone Bolelli ITA | 40 | 21 | 19 | 0.525 | 1 | 0 |
| 31 | Tomas Berdych CZE | 33 | 20 | 13 | 0.606 | 2 | 1 |
| 32 | Albert Montanes ESP | 36 | 20 | 16 | 0.556 | 1 | 2 |
| 33 | Mardy Fish USA | 37 | 20 | 17 | 0.541 | 0 | 0 |
| 34 | Jose Acasuso ARG | 38 | 20 | 18 | 0.526 | 1 | 2 |
| 35 | Juan Martin Del Potro ARG | 27 | 19 | 8 | 0.704 | 1 | 0 |
| 36 | Nicolas Kiefer GER | 29 | 19 | 10 | 0.655 | 1 | 0 |
| 37 | Michael Llodra FRA | 33 | 19 | 14 | 0.576 | 0 | 1 |
| 38 | Guillermo Canas ARG | 33 | 19 | 14 | 0.576 | 0 | 1 |
| 39 | Janko Tipsarevic SRB | 34 | 19 | 15 | 0.559 | 2 | 2 |
| 40 | Carlos Moya ESP | 36 | 19 | 17 | 0.528 | 1 | 0 |