| Rank | Player | Matches | Wins | Losses | PCT | 6-0 | 0-6 |
| 1 | Rafael Nadal ESP | 60 | 53 | 7 | 0.883 | 5 | 0 |
| 2 | Andy Roddick USA | 50 | 40 | 10 | 0.800 | 0 | 0 |
| 3 | Roger Federer SUI | 50 | 40 | 10 | 0.800 | 4 | 0 |
| 4 | David Nalbandian ARG | 25 | 20 | 5 | 0.800 | 4 | 0 |
| 5 | David Ferrer ESP | 56 | 42 | 14 | 0.750 | 7 | 1 |
| 6 | Juan Martin Del Potro ARG | 4 | 3 | 1 | 0.750 | 0 | 1 |
| 7 | Richard Bloomfield GBR | 4 | 3 | 1 | 0.750 | 0 | 0 |
| 8 | Novak Djokovic SRB | 47 | 35 | 12 | 0.745 | 1 | 1 |
| 9 | Andy Murray GBR | 45 | 33 | 12 | 0.733 | 1 | 2 |
| 10 | Fernando Verdasco ESP | 53 | 38 | 15 | 0.717 | 3 | 3 |
| 11 | Mardy Fish USA | 49 | 35 | 14 | 0.714 | 5 | 1 |
| 12 | Robin Soderling SWE | 49 | 35 | 14 | 0.714 | 5 | 0 |
| 13 | Tomas Berdych CZE | 54 | 38 | 16 | 0.704 | 4 | 0 |
| 14 | Marin Cilic CRO | 47 | 33 | 14 | 0.702 | 1 | 1 |
| 15 | Jo-Wilfried Tsonga FRA | 36 | 25 | 11 | 0.694 | 1 | 0 |
| 16 | Juan Carlos Ferrero ESP | 45 | 31 | 14 | 0.689 | 4 | 1 |
| 17 | Nikolay Davydenko RUS | 32 | 22 | 10 | 0.688 | 5 | 2 |
| 18 | Nicolas Almagro ESP | 54 | 37 | 17 | 0.685 | 2 | 1 |
| 19 | John Isner USA | 44 | 30 | 14 | 0.682 | 0 | 1 |
| 20 | Sam Querrey USA | 48 | 32 | 16 | 0.667 | 2 | 0 |
| 21 | Mikhail Youzhny RUS | 42 | 28 | 14 | 0.667 | 2 | 0 |
| 22 | Stanislas Wawrinka SUI | 39 | 26 | 13 | 0.667 | 0 | 1 |
| 23 | Yuri Schukin KAZ | 6 | 4 | 2 | 0.667 | 0 | 0 |
| 24 | Ricardas Berankis LTU | 6 | 4 | 2 | 0.667 | 1 | 0 |
| 25 | Reda El Amrani MAR | 3 | 2 | 1 | 0.667 | 0 | 0 |
| 26 | Peter Polansky CAN | 3 | 2 | 1 | 0.667 | 0 | 0 |
| 27 | Ivo Karlovic CRO | 25 | 16 | 9 | 0.640 | 0 | 0 |
| 28 | Jurgen Melzer AUT | 55 | 35 | 20 | 0.636 | 3 | 0 |
| 29 | Philipp Kohlschreiber GER | 44 | 28 | 16 | 0.636 | 5 | 0 |
| 30 | Ernests Gulbis LAT | 41 | 26 | 15 | 0.634 | 0 | 0 |
| 31 | Gael Monfils FRA | 38 | 24 | 14 | 0.632 | 2 | 0 |
| 32 | Albert Montanes ESP | 46 | 29 | 17 | 0.630 | 3 | 1 |
| 33 | Richard Gasquet FRA | 43 | 27 | 16 | 0.628 | 4 | 1 |
| 34 | Lleyton Hewitt AUS | 29 | 18 | 11 | 0.621 | 5 | 0 |
| 35 | Marcos Baghdatis CYP | 57 | 35 | 22 | 0.614 | 2 | 2 |
| 36 | Thomaz Bellucci BRA | 48 | 29 | 19 | 0.604 | 1 | 3 |
| 37 | Juan Monaco ARG | 35 | 21 | 14 | 0.600 | 2 | 1 |
| 38 | Michael Lammer SUI | 5 | 3 | 2 | 0.600 | 0 | 0 |
| 39 | Rui Machado POR | 5 | 3 | 2 | 0.600 | 0 | 0 |
| 40 | Raven Klaasen RSA | 5 | 3 | 2 | 0.600 | 0 | 0 |