| Rank | Player | Matches | Wins | Losses | PCT | 6-0 | 0-6 |
| 1 | Rafael Nadal ESP | 61 | 54 | 7 | 0.885 | 7 | 1 |
| 2 | Roger Federer SUI | 51 | 43 | 8 | 0.843 | 4 | 1 |
| 3 | Younes El Aynaoui MAR | 6 | 5 | 1 | 0.833 | 0 | 0 |
| 4 | Novak Djokovic SRB | 46 | 38 | 8 | 0.826 | 8 | 0 |
| 5 | Nikolay Davydenko RUS | 49 | 38 | 11 | 0.776 | 3 | 0 |
| 6 | Andy Roddick USA | 31 | 24 | 7 | 0.774 | 0 | 0 |
| 7 | Fernando Gonzalez CHI | 29 | 22 | 7 | 0.759 | 2 | 0 |
| 8 | David Ferrer ESP | 45 | 33 | 12 | 0.733 | 4 | 2 |
| 9 | Nicolas Almagro ESP | 41 | 30 | 11 | 0.732 | 0 | 0 |
| 10 | Sergiy Stakhovsky UKR | 7 | 5 | 2 | 0.714 | 0 | 0 |
| 11 | Andy Murray GBR | 38 | 27 | 11 | 0.711 | 6 | 1 |
| 12 | Mario Ancic CRO | 38 | 26 | 12 | 0.684 | 2 | 1 |
| 13 | David Nalbandian ARG | 31 | 21 | 10 | 0.677 | 1 | 2 |
| 14 | James Blake USA | 40 | 27 | 13 | 0.675 | 1 | 0 |
| 15 | Jo-Wilfried Tsonga FRA | 24 | 16 | 8 | 0.667 | 1 | 2 |
| 16 | Jeremy Chardy FRA | 6 | 4 | 2 | 0.667 | 0 | 0 |
| 17 | Mikhail Kukushkin RUS | 3 | 2 | 1 | 0.667 | 1 | 0 |
| 18 | Simon Stadler GER | 3 | 2 | 1 | 0.667 | 0 | 0 |
| 19 | Stanislas Wawrinka SUI | 38 | 25 | 13 | 0.658 | 2 | 0 |
| 20 | Radek Stepanek CZE | 35 | 23 | 12 | 0.657 | 3 | 1 |
| 21 | Robin Soderling SWE | 32 | 21 | 11 | 0.656 | 1 | 2 |
| 22 | Juan Monaco ARG | 37 | 24 | 13 | 0.649 | 2 | 1 |
| 23 | Mikhail Youzhny RUS | 31 | 20 | 11 | 0.645 | 3 | 2 |
| 24 | Lleyton Hewitt AUS | 27 | 17 | 10 | 0.630 | 3 | 0 |
| 25 | Robby Ginepri USA | 26 | 16 | 10 | 0.615 | 1 | 0 |
| 26 | Michael Llodra FRA | 31 | 19 | 12 | 0.613 | 0 | 1 |
| 27 | Philipp Kohlschreiber GER | 28 | 17 | 11 | 0.607 | 0 | 0 |
| 28 | Fernando Verdasco ESP | 40 | 24 | 16 | 0.600 | 3 | 1 |
| 29 | Tomas Berdych CZE | 25 | 15 | 10 | 0.600 | 2 | 1 |
| 30 | Janko Tipsarevic SRB | 32 | 19 | 13 | 0.594 | 2 | 2 |
| 31 | Guillermo Canas ARG | 27 | 16 | 11 | 0.593 | 0 | 1 |
| 32 | Gael Monfils FRA | 22 | 13 | 9 | 0.591 | 2 | 0 |
| 33 | Nicolas Kiefer GER | 22 | 13 | 9 | 0.591 | 1 | 0 |
| 34 | Tommy Robredo ESP | 34 | 20 | 14 | 0.588 | 0 | 1 |
| 35 | Paul-Henri Mathieu FRA | 36 | 21 | 15 | 0.583 | 2 | 0 |
| 36 | Dmitry Tursunov RUS | 31 | 18 | 13 | 0.581 | 2 | 1 |
| 37 | Mardy Fish USA | 33 | 19 | 14 | 0.576 | 0 | 0 |
| 38 | Juan Carlos Ferrero ESP | 28 | 16 | 12 | 0.571 | 0 | 0 |
| 39 | Marcel Granollers ESP | 21 | 12 | 9 | 0.571 | 2 | 1 |
| 40 | Marcos Baghdatis CYP | 21 | 12 | 9 | 0.571 | 0 | 1 |