| Rank | Player | Matches | Wins | Losses | PCT | 6-0 | 0-6 |
| 1 | Rafael Nadal ESP | 83 | 74 | 9 | 0.892 | 10 | 1 |
| 2 | Novak Djokovic SRB | 69 | 56 | 13 | 0.812 | 8 | 0 |
| 3 | Andy Murray GBR | 55 | 41 | 14 | 0.745 | 7 | 2 |
| 4 | Fernando Verdasco ESP | 65 | 41 | 24 | 0.631 | 6 | 2 |
| 5 | Roger Federer SUI | 66 | 54 | 12 | 0.818 | 6 | 1 |
| 6 | Julien Benneteau FRA | 37 | 18 | 19 | 0.486 | 4 | 2 |
| 7 | Stanislas Wawrinka SUI | 51 | 33 | 18 | 0.647 | 4 | 1 |
| 8 | David Ferrer ESP | 59 | 40 | 19 | 0.678 | 4 | 2 |
| 9 | Lleyton Hewitt AUS | 29 | 18 | 11 | 0.621 | 3 | 0 |
| 10 | Mikhail Youzhny RUS | 42 | 25 | 17 | 0.595 | 3 | 2 |
| 11 | Marc Gicquel FRA | 43 | 21 | 22 | 0.488 | 3 | 1 |
| 12 | Tomas Berdych CZE | 45 | 29 | 16 | 0.644 | 3 | 1 |
| 13 | Juan Martin Del Potro ARG | 47 | 37 | 10 | 0.787 | 3 | 0 |
| 14 | Radek Stepanek CZE | 47 | 29 | 18 | 0.617 | 3 | 1 |
| 15 | Fernando Gonzalez CHI | 50 | 36 | 14 | 0.720 | 3 | 1 |
| 16 | Robin Soderling SWE | 50 | 33 | 17 | 0.660 | 3 | 2 |
| 17 | Dmitry Tursunov RUS | 50 | 32 | 18 | 0.640 | 3 | 1 |
| 18 | Paul-Henri Mathieu FRA | 54 | 31 | 23 | 0.574 | 3 | 0 |
| 19 | Nikolay Davydenko RUS | 61 | 45 | 16 | 0.738 | 3 | 0 |
| 20 | Sebastien Grosjean FRA | 22 | 8 | 14 | 0.364 | 2 | 1 |
| 21 | Santiago Ventura ESP | 24 | 8 | 16 | 0.333 | 2 | 0 |
| 22 | Teimuraz Gabashvili RUS | 25 | 13 | 12 | 0.520 | 2 | 0 |
| 23 | Jesse Levine USA | 25 | 8 | 17 | 0.320 | 2 | 0 |
| 24 | Evgeny Korolev RUS | 29 | 13 | 16 | 0.448 | 2 | 1 |
| 25 | Marcel Granollers ESP | 30 | 13 | 17 | 0.433 | 2 | 1 |
| 26 | Jo-Wilfried Tsonga FRA | 33 | 23 | 10 | 0.697 | 2 | 2 |
| 27 | Steve Darcis BEL | 36 | 18 | 18 | 0.500 | 2 | 3 |
| 28 | Robby Ginepri USA | 39 | 22 | 17 | 0.564 | 2 | 1 |
| 29 | Rainer Schuettler GER | 39 | 19 | 20 | 0.487 | 2 | 3 |
| 30 | Potito Starace ITA | 39 | 18 | 21 | 0.462 | 2 | 0 |
| 31 | Gael Monfils FRA | 40 | 26 | 14 | 0.650 | 2 | 1 |
| 32 | Mario Ancic CRO | 42 | 28 | 14 | 0.667 | 2 | 1 |
| 33 | Juan Monaco ARG | 42 | 25 | 17 | 0.595 | 2 | 1 |
| 34 | Janko Tipsarevic SRB | 42 | 23 | 19 | 0.548 | 2 | 2 |
| 35 | Guillermo Garcia-Lopez ESP | 42 | 21 | 21 | 0.500 | 2 | 4 |
| 36 | Jarkko Nieminen FIN | 46 | 22 | 24 | 0.478 | 2 | 0 |
| 37 | Mardy Fish USA | 51 | 30 | 21 | 0.588 | 2 | 0 |
| 38 | Jurgen Melzer AUT | 52 | 29 | 23 | 0.558 | 2 | 2 |
| 39 | Andreas Seppi ITA | 52 | 27 | 25 | 0.519 | 2 | 0 |
| 40 | James Blake USA | 57 | 39 | 18 | 0.684 | 2 | 0 |