| Rank | Player | Matches | Wins | Losses | PCT | 6-0 | 0-6 |
| 1 | Andy Murray GBR | 87 | 78 | 9 | 0.897 | 8 | 0 |
| 2 | John Millman AUS | 40 | 19 | 21 | 0.475 | 6 | 0 |
| 3 | Rafael Nadal ESP | 52 | 39 | 13 | 0.750 | 6 | 0 |
| 4 | Albert Ramos-Vinolas ESP | 65 | 34 | 31 | 0.523 | 6 | 0 |
| 5 | Gilles Simon FRA | 59 | 33 | 26 | 0.559 | 5 | 1 |
| 6 | David Goffin BEL | 74 | 49 | 25 | 0.662 | 5 | 2 |
| 7 | Dominic Thiem AUT | 80 | 56 | 24 | 0.700 | 5 | 1 |
| 8 | Juan Martin Del Potro ARG | 44 | 32 | 12 | 0.727 | 4 | 0 |
| 9 | Paolo Lorenzi ITA | 51 | 26 | 25 | 0.510 | 4 | 3 |
| 10 | Richard Gasquet FRA | 53 | 35 | 18 | 0.660 | 4 | 2 |
| 11 | Gael Monfils FRA | 61 | 44 | 17 | 0.721 | 4 | 2 |
| 12 | Diego Schwartzman ARG | 34 | 17 | 17 | 0.500 | 3 | 4 |
| 13 | Damir Dzumhur BIH | 42 | 20 | 22 | 0.476 | 3 | 3 |
| 14 | Marcos Baghdatis CYP | 49 | 26 | 23 | 0.531 | 3 | 1 |
| 15 | Pablo Carreno Busta ESP | 66 | 40 | 26 | 0.606 | 3 | 4 |
| 16 | Novak Djokovic SRB | 74 | 65 | 9 | 0.878 | 3 | 1 |
| 17 | Kei Nishikori JPN | 78 | 57 | 21 | 0.731 | 3 | 0 |
| 18 | Daniil Medvedev RUS | 10 | 5 | 5 | 0.500 | 2 | 0 |
| 19 | Tobias Kamke GER | 10 | 5 | 5 | 0.500 | 2 | 0 |
| 20 | Mischa Zverev GER | 26 | 12 | 14 | 0.462 | 2 | 1 |
| 21 | Denis Kudla USA | 28 | 8 | 20 | 0.286 | 2 | 4 |
| 22 | Martin Klizan SVK | 29 | 14 | 15 | 0.483 | 2 | 1 |
| 23 | Paul-Henri Mathieu FRA | 37 | 18 | 19 | 0.486 | 2 | 0 |
| 24 | Jeremy Chardy FRA | 38 | 17 | 21 | 0.447 | 2 | 1 |
| 25 | Guido Pella ARG | 39 | 16 | 23 | 0.410 | 2 | 1 |
| 26 | Lukas Rosol CZE | 40 | 16 | 24 | 0.400 | 2 | 0 |
| 27 | Dusan Lajovic SRB | 42 | 19 | 23 | 0.452 | 2 | 3 |
| 28 | Jiri Vesely CZE | 43 | 21 | 22 | 0.488 | 2 | 0 |
| 29 | Andreas Seppi ITA | 45 | 20 | 25 | 0.444 | 2 | 1 |
| 30 | Andrey Kuznetsov RUS | 49 | 28 | 21 | 0.571 | 2 | 1 |
| 31 | Fabio Fognini ITA | 49 | 26 | 23 | 0.531 | 2 | 2 |
| 32 | Sam Querrey USA | 51 | 28 | 23 | 0.549 | 2 | 0 |
| 33 | Federico Delbonis ARG | 51 | 27 | 24 | 0.529 | 2 | 1 |
| 34 | David Ferrer ESP | 58 | 36 | 22 | 0.621 | 2 | 0 |
| 35 | Tomas Berdych CZE | 59 | 39 | 20 | 0.661 | 2 | 2 |
| 36 | Viktor Troicki SRB | 63 | 34 | 29 | 0.540 | 2 | 0 |
| 37 | Milos Raonic CAN | 69 | 52 | 17 | 0.754 | 2 | 2 |
| 38 | Marin Cilic CRO | 71 | 48 | 23 | 0.676 | 2 | 0 |
| 39 | Omar Jasika AUS | 2 | 1 | 1 | 0.500 | 1 | 0 |
| 40 | Alessandro Giannessi ITA | 2 | 1 | 1 | 0.500 | 1 | 1 |