| Rank | Player | Matches | Wins | Losses | PCT | 6-0 | 0-6 |
| 1 | Jelena Jankovic SRB | 84 | 65 | 19 | 0.774 | 7 | 1 |
| 2 | Vera Zvonareva RUS | 84 | 62 | 22 | 0.738 | 16 | 2 |
| 3 | Elena Dementieva RUS | 73 | 56 | 17 | 0.767 | 10 | 3 |
| 4 | Dinara Safina RUS | 74 | 55 | 19 | 0.743 | 7 | 1 |
| 5 | Caroline Wozniacki DEN | 73 | 53 | 20 | 0.726 | 12 | 2 |
| 6 | Agnieszka Radwanska POL | 71 | 51 | 20 | 0.718 | 11 | 2 |
| 7 | Flavia Pennetta ITA | 73 | 50 | 23 | 0.685 | 7 | 1 |
| 8 | Nadia Petrova RUS | 71 | 47 | 24 | 0.662 | 4 | 2 |
| 9 | Serena Williams USA | 52 | 44 | 8 | 0.846 | 6 | 1 |
| 10 | Svetlana Kuznetsova RUS | 62 | 41 | 21 | 0.661 | 3 | 0 |
| 11 | Katarina Srebotnik SLO | 65 | 41 | 24 | 0.631 | 11 | 1 |
| 12 | Venus Williams USA | 51 | 40 | 11 | 0.784 | 3 | 0 |
| 13 | Victoria Azarenka BLR | 60 | 40 | 20 | 0.667 | 6 | 1 |
| 14 | Anabel Medina Garrigues ESP | 65 | 40 | 25 | 0.615 | 9 | 3 |
| 15 | Ana Ivanovic SRB | 53 | 38 | 15 | 0.717 | 6 | 1 |
| 16 | Dominika Cibulkova SVK | 62 | 36 | 26 | 0.581 | 1 | 3 |
| 17 | Alize Cornet FRA | 57 | 35 | 22 | 0.614 | 4 | 2 |
| 18 | Maria Kirilenko RUS | 56 | 34 | 22 | 0.607 | 6 | 1 |
| 19 | Patty Schnyder SUI | 56 | 34 | 22 | 0.607 | 4 | 2 |
| 20 | Maria Sharapova RUS | 34 | 30 | 4 | 0.882 | 9 | 0 |
| 21 | Amelie Mauresmo FRA | 49 | 30 | 19 | 0.612 | 6 | 2 |
| 22 | Kaia Kanepi EST | 51 | 30 | 21 | 0.588 | 8 | 4 |
| 23 | Sara Errani ITA | 51 | 29 | 22 | 0.569 | 3 | 3 |
| 24 | Marion Bartoli FRA | 55 | 29 | 26 | 0.527 | 7 | 5 |
| 25 | Na Li CHN | 41 | 28 | 13 | 0.683 | 4 | 2 |
| 26 | Sybille Bammer AUT | 52 | 27 | 25 | 0.519 | 3 | 7 |
| 27 | Alona Bondarenko UKR | 47 | 26 | 21 | 0.553 | 1 | 5 |
| 28 | Agnes Szavay HUN | 51 | 26 | 25 | 0.510 | 1 | 3 |
| 29 | Sorana Cirstea ROU | 42 | 25 | 17 | 0.595 | 2 | 6 |
| 30 | Shahar Peer ISR | 46 | 25 | 21 | 0.543 | 8 | 2 |
| 31 | Ai Sugiyama JPN | 47 | 25 | 22 | 0.532 | 2 | 2 |
| 32 | Anna Chakvetadze RUS | 48 | 25 | 23 | 0.521 | 2 | 0 |
| 33 | Shuai Peng CHN | 48 | 25 | 23 | 0.521 | 3 | 3 |
| 34 | Francesca Schiavone ITA | 46 | 24 | 22 | 0.522 | 2 | 2 |
| 35 | Lindsay Davenport USA | 27 | 23 | 4 | 0.852 | 3 | 0 |
| 36 | Jie Zheng CHN | 33 | 22 | 11 | 0.667 | 4 | 0 |
| 37 | Daniela Hantuchova SVK | 42 | 22 | 20 | 0.524 | 2 | 2 |
| 38 | Jill Craybas USA | 48 | 22 | 26 | 0.458 | 4 | 4 |
| 39 | Iveta Benesova CZE | 39 | 21 | 18 | 0.538 | 2 | 1 |
| 40 | Olga Govortsova BLR | 47 | 21 | 26 | 0.447 | 2 | 5 |