| Rank | Player | Matches | Wins | Losses | PCT | 6-0 | 0-6 |
| 1 | Vera Zvonareva RUS | 84 | 62 | 22 | 0.738 | 16 | 2 |
| 2 | Caroline Wozniacki DEN | 73 | 53 | 20 | 0.726 | 12 | 2 |
| 3 | Katarina Srebotnik SLO | 65 | 41 | 24 | 0.631 | 11 | 1 |
| 4 | Agnieszka Radwanska POL | 71 | 51 | 20 | 0.718 | 11 | 2 |
| 5 | Elena Dementieva RUS | 73 | 56 | 17 | 0.767 | 10 | 3 |
| 6 | Maria Sharapova RUS | 34 | 30 | 4 | 0.882 | 9 | 0 |
| 7 | Anabel Medina Garrigues ESP | 65 | 40 | 25 | 0.615 | 9 | 3 |
| 8 | Shahar Peer ISR | 46 | 25 | 21 | 0.543 | 8 | 2 |
| 9 | Kaia Kanepi EST | 51 | 30 | 21 | 0.588 | 8 | 4 |
| 10 | Marion Bartoli FRA | 55 | 29 | 26 | 0.527 | 7 | 5 |
| 11 | Flavia Pennetta ITA | 73 | 50 | 23 | 0.685 | 7 | 1 |
| 12 | Dinara Safina RUS | 74 | 55 | 19 | 0.743 | 7 | 1 |
| 13 | Jelena Jankovic SRB | 84 | 65 | 19 | 0.774 | 7 | 1 |
| 14 | Amelie Mauresmo FRA | 49 | 30 | 19 | 0.612 | 6 | 2 |
| 15 | Serena Williams USA | 52 | 44 | 8 | 0.846 | 6 | 1 |
| 16 | Ana Ivanovic SRB | 53 | 38 | 15 | 0.717 | 6 | 1 |
| 17 | Maria Kirilenko RUS | 56 | 34 | 22 | 0.607 | 6 | 1 |
| 18 | Victoria Azarenka BLR | 60 | 40 | 20 | 0.667 | 6 | 1 |
| 19 | Nuria Llagostera Vives ESP | 25 | 14 | 11 | 0.560 | 5 | 3 |
| 20 | Alisa Kleybanova RUS | 32 | 17 | 15 | 0.531 | 5 | 1 |
| 21 | Sabine Lisicki GER | 34 | 16 | 18 | 0.471 | 5 | 1 |
| 22 | Jie Zheng CHN | 33 | 22 | 11 | 0.667 | 4 | 0 |
| 23 | Bethanie Mattek USA | 33 | 19 | 14 | 0.576 | 4 | 3 |
| 24 | Na Li CHN | 41 | 28 | 13 | 0.683 | 4 | 2 |
| 25 | Jill Craybas USA | 48 | 22 | 26 | 0.458 | 4 | 4 |
| 26 | Patty Schnyder SUI | 56 | 34 | 22 | 0.607 | 4 | 2 |
| 27 | Alize Cornet FRA | 57 | 35 | 22 | 0.614 | 4 | 2 |
| 28 | Nadia Petrova RUS | 71 | 47 | 24 | 0.662 | 4 | 2 |
| 29 | Lindsay Davenport USA | 27 | 23 | 4 | 0.852 | 3 | 0 |
| 30 | Nathalie Dechy FRA | 29 | 13 | 16 | 0.448 | 3 | 0 |
| 31 | Samantha Stosur AUS | 30 | 18 | 12 | 0.600 | 3 | 1 |
| 32 | Tamarine Tanasugarn THA | 34 | 19 | 15 | 0.559 | 3 | 1 |
| 33 | Tsvetana Pironkova BUL | 34 | 16 | 18 | 0.471 | 3 | 1 |
| 34 | Tamira Paszek AUT | 34 | 16 | 18 | 0.471 | 3 | 4 |
| 35 | Nicole Vaidisova CZE | 36 | 17 | 19 | 0.472 | 3 | 5 |
| 36 | Camille Pin FRA | 38 | 16 | 22 | 0.421 | 3 | 2 |
| 37 | Shuai Peng CHN | 48 | 25 | 23 | 0.521 | 3 | 3 |
| 38 | Venus Williams USA | 51 | 40 | 11 | 0.784 | 3 | 0 |
| 39 | Sara Errani ITA | 51 | 29 | 22 | 0.569 | 3 | 3 |
| 40 | Sybille Bammer AUT | 52 | 27 | 25 | 0.519 | 3 | 7 |